Facilities
Instrumentation
Bruker amaZon Ion Trap (~2012) Mass Spectrometer with CTD & ETD
Th Bruker 3D ion trap is the work-horse for most of our
CTD experiments. We duplicated the capability with our collaborators, Dr. Hélène Rogniaux and Dr. David Ropartz, at the
BIBS MS platform INRAE in Nantes, France. This instrument is also compatible with UHPLC to accomplish
UHPLC-CTD-MS of complex mixtures of oligosaccharides.
Thermo Scientific Velos Pro (~2012) Linear Ion Trap Mass Spectrometer with ETD
& CTD
Our linear ion trap is primarily used for MS
2 and MS
n fragmentation studies of novel psychoactive substances (NPSs). The instrument
is also modified to enable
Charge Transfer Dissociation (CTD) reactions.
Thermo Finnigan Delta V (~2012) with Trace GC-Combustion interface and Flash
EA
This magnetic sector instrument is capable of bulk
13C,
15N and
34S (simultaneously) through the Flash EA, and compound-specific
13C via the GC-combustion interface. Previously, we have used a Dionex HPLC-Isolink
interface to achieve compound-specific isotope analysis, but the GC-C interface is
more reliable in our hands. The GC-C-IRMS instrument is currently being used
for amino acids in human hair and insects.
Agilent 6538 UHD Accurate Mass Q-TOF (~2010)
This Q-TOF, kindly donated by the FDA, is operated with either ESI or DART ion
sources, and has typically been used for accurate mass measurements of novel
psychoactive substances and fentanyl analogs.