Our long-term goal is to catalyze the progress of biomedical, analytical and forensic
research through the development of mass spectrometric instruments and techniques.
We currently have several major projects under way:
- Development of an Expert Algorithm for Substance Identification (EASI), which was first published in two parts, here: Part 1--Foundations in RRKM theory, and Part 2--Application to the identification of cocaine. This research has also received the 2021 FACSS Innovation Award and NIJ funding.
- New ways of fragmenting gas-phase bio-ions in tandem mass spectrometers using
kiloelectronvolt helium ions. We use the term charge transfer dissociation
(CTD-MS) to describe the mechanism of activation. See example publications
for
peptides,
glycosaminoglycans and
HPLC-CTD-MS of oligogalacturonans.
- New forensic applications of isotope ratio mass spectrometry, including hair,
nails and blow flies. We use both LC-IRMS and GC-C-IRMS to analyze the
13C abundances of the different amino acids in proteinaceous material.
See example publications for
hair,
blowflies and
oysters.
- Understanding the mass spectrometric fragmentation behavior of novel psychoactive substances (NPSs) and fentanyl analogs. See example publications for cathinones and fentalogs, including a novel rearrangement for fentalogs.
- Developing experimental and theoretical approaches to understand the evaporation of ignitable liquids at elevated temperatures (e.g., 210 °C). See example publication.
Click on the publications tab in the menu bar to
see all our recent publications.
DR. JACKSON SERVES AS FACSS/SCIX PHOTOGRAPHER (OCT 2024)
Since 2017, Dr. Jackson has provided photography services to
FACSS at the annual
SciX conference. Video montages of the conference are available on the
SciX YouTube Channel. An example video from the 2024 SciX meeting in Raleigh,
NC, is provided below. This video includes pictures from the gala on the closing
night with the theme of Team Spirit! Dr. Jackson also chaired a session on
"Novel Instrumentation, Analysis Tools, and Chemistry in Mass Spectrometry"
and gave an oral presentation talk on unintended ion-molecule reactions in
the tandem mass spectrometry of NPSs.
Dr. Jackson
received the 2024
Travis Stimeling Award for Mentoring Undergraduates in Research
in the area of Physical Sciences and Technology. Dr. Jackson is sincerely grateful
to
Dr. Richards-Babb in Chemistry and
Dr. Venter in Forensic and Investigative Science, who nominated him, and
to all the past and present undergraduate researchers for their contributions.
In addition to their time and commitment in the lab, many former and present
undergraduate researchers were also kind enough to write letters of support.
One part of the application included
a summary of their amazing accomplishments.
Congratulations to Alex for receiving the Forensic Science Foundation's
2024 Student Affiliate Scholarship to defray the cost of attending the
American Academy of Forensic Sciences (AAFS) meeting in Denver, CO in February.
Alex will be giving an oral presentation of her research on the expert algorithm
for substance identification (EASI), which she is applying to help resolve
and identify structural isomers of drugs like fentanyl analogs.
DR. JACKSON SERVES AS FACSS/SCIX PHOTOGRAPHER (OCT 2023)
Since 2017, Dr. Jackson has provided photography services to
FACSS
at the annual
SciX conference.
Video montages of the conference are available on the
SciX YouTube Channel.
An example video from the 2023 SciX meeting in Sparks, NV, is provided below. This
video includes pictures from the 70s-themed gala on the closing night.
Latest News
DR. JACKSON SERVES AS FACSS/SCIX PHOTOGRAPHER (OCT 2024)
Since 2017, Dr. Jackson has provided photography services to
FACSS at the annual
SciX conference. Video montages of the conference are available on the
SciX YouTube Channel. An example video from the 2024 SciX meeting in Raleigh,
NC, is provided below. This video includes pictures from the gala on the closing
night with the theme of Team Spirit! Dr. Jackson also chaired a session on
"Novel Instrumentation, Analysis Tools, and Chemistry in Mass Spectrometry"
and gave an oral presentation talk on unintended ion-molecule reactions in
the tandem mass spectrometry of NPSs.GROUP RECEIVES NEW NIJ GRANT (OCT 2024)
The National Institute of Justice (NIJ)
recently announced that our proposal titled "Expert Algorithm to Identify Seized Drugs from Tandem Mass Spectra" will
be funded in the amount of $400K starting January 1, 2025. WVU Today has also reported on the new grant. The proposal is
a collaboration with the Drug Enforcement Administration (DEA) and Wiley's
mass spectrometry database group. We plan to develop the Expert Algorithm for
Substance Identification (EASI) to help resolve the spectra of drug isomers from DART-MS/MS and ESI-MS/MS
data. Unlike machine-learning algorithms—where the rules behind the decision-making
processes are difficult to explicate—the modeling within
EASI is based on
the Rice-Ramsperger-Kassel-Marcus (RRKM) theory of unimolecular dissociation,
so EASI has a strong and transparent scientific foundation. The figure below
demonstrates that relative ion abundances in tandem mass spectra are expected
to follow approximately linear relationships with one another, even when the
internal energy of the decomposing ion varies, such as between instruments
and laboratories.
INTERVIEW WITH DR. JACKSON APPEARS ON FORENSICS COLLEGES WEBSITE (SEPT 2024)
WVU's
forensic chemistry program is identified as one of the best in the country
by forensicscolleges.com. As part of their mission to help inform prospective students
about degree programs and careers in the forensic sciences, they interviewed
Dr. Jackson about careers in forensic chemistry. His interview is featured
in a section
titled "Meet the expert
."
DR. JACKSON APPEARS IN NEW PROMOTIONAL VIDEO FOR WVU (AUG 2024)
WVU released
this video at the
2024 WV Annual Meeting and Business Summit at the Greenbrier Resort in
White Sulphur Springs, WV on August 28, 2024. The meeting, hosted by the
WV Chamber of Commerce, provided WVU with an opportunity to showcase how
the University contributes to the State's economy and prosperity. Our forensic
science program was among several of WVU's select programs to be highlighted
in the video. Coverage of
the forensic program starts at 3:12 mins on this Vimeo link.
DR. JACKSON PROMOTED TO MEMBER OF CSFS (JUL 2024)
Dr. Jackson was recently promoted to
Member of the
Chartered Society of Forensic Sciences (CSFS). The CSFS is a non-profit
organization based in the UK that
evolved from the Forensic Science Society, which was established in 1959.
The CSFS received its Royal Charter in 2014. The CSFS: promotes develops regulation;
provides opportunities for education, training development; and supports and
encourages research development in the forensic sciences.
HANNAH RECEIVES STEM GRADUATE FELLOWSHIP (MAY 2024)
Congratulations, Hannah, for receiving a
STEM graduate fellowship award from the Provost's office to pursue her
PhD in Forensic Science here at WVU. The award provides a tuition waiver and
a generous stipend for up to 3 years.
ALEX, SARAH AND HANNAH GRADUATE (MAY 2024)
Congratulations to Alex Pfeffer and Sarah Mosinski for completing undergraduate
degrees in biochemistry and FIS, respectively. Congratulations to Hannah McMillen,
also, for successfully defending her thesis on "The Application of the Expert
Algorithm for Substance Identification (EASI) to Predict ASTM E1618-19 Ignitable
Liquid Classes from Gas Chromatography-Mass Spectrometry Data of Ignitable
Liquid Residues." Sarah will be staying at WVU to complete her MS in FIS with
Dr. Speir in FIS, and Hannah will be staying at WVU to complete her PhD
in FS with Dr. Jackson.
DR. JACKSON RECEIVES UNDERGRADUATE MENTORING AWARD FROM WVU (APRIL 2024)
Dr. Jackson
received the 2024
Travis Stimeling Award for Mentoring Undergraduates in Research
in the area of Physical Sciences and Technology. Dr. Jackson is sincerely grateful
to
Dr. Richards-Babb in Chemistry and
Dr. Venter in Forensic and Investigative Science, who nominated him, and
to all the past and present undergraduate researchers for their contributions.
In addition to their time and commitment in the lab, many former and present
undergraduate researchers were also kind enough to write letters of support.
One part of the application included
a summary of their amazing accomplishments.
ALEX ADEOYE RECEIVES 2024 FSF STUDENT AFFILIATE SCHOLARSHIP TO ATTEND AFFS CONFERENCE (DEC 2023)
DR. JACKSON GIVES PLENARY LECTURE FOR TOXICOLOGY WORKSHOP (DEC, 2023)
In December 2023, The American College of Medical toxicology (ACMT) and the Center for Forensic Science Research and Education (CFSRE) presented a one-day on-line forensic toxicology workshop titled "Cannabis and the Expanding World of Cannabinoids." Dr. Jackson was invited to give the introductory presentation with the title "How Did We Get Here? Cannabis Legalization, the Farm Bill, Cannabinoid Analogues, Chemistry." The live workshop was attended by more than 220 attendees from around the world, and the recording is available for continuing education (CE) credit through ACMT's website.DR. JACKSON SERVES AS FACSS/SCIX PHOTOGRAPHER (OCT 2023)
Since 2017, Dr. Jackson has provided photography services to
FACSS
at the annual
SciX conference.
Video montages of the conference are available on the
SciX YouTube Channel.
An example video from the 2023 SciX meeting in Sparks, NV, is provided below. This
video includes pictures from the 70s-themed gala on the closing night.
DR. JACKSON QUOTED IN NYT ARTICLE (SEPT 2023)
A writer form the New York Times reached out to Dr. Jackson to ask his scientific
opinion on how hard it would be for toxicology labs in the US to develop LC-MS
methods to detect abortion drugs and their metabolites in human body fluids.
A link to the article is
here.
IZZY, CHRIS, AND MAX COMPLETE MS DEGREES (AUG 2023)
Congratulations to Isabel Galvez, Chris Poulos and Max Denn for successfully
completing their MS degrees. All three will graduate in August 2023. Chris
has already started a fellowship at the FDA Forensic Chemistry Center in Cincinnati,
OH, and Max is employed at the Center for Forensic Science Research and Education
(CFSRE) in Willow Grove, PA.
CHANEY GRADUATES (MAY 2023)
Congratulations to Chaney for graduating with a BS in Forensic Chemistry and
a minor in Criminology. Chaney will be staying in the Jackson Group to pursue
her M.S. Degree in Forensic and Investigative Science.
GROUP ATTENDS/PRESENTS AT AAFS CONFERENCE (FEB 2023)
The Jackson group gave two oral presentations and four poster presentations at
the annual meeting of the American Academy of Forensic Sciences (AAFS) in Orlando,
FL.
ALEX ADEOYE WINS FORENSIC SCIENCE FOUNDATION TRAVEL AWARD (JAN 2023)
Alex Adeoye was one of eight recipients of the Forensic Science Foundation's
(FSF) Student Travel Grant. The grant supported the presentation of her research
on the Expert Algorithm for Substance Identification (EASI) at the 2023 meeting
of the American Academy of Forensic Sciences (AAFS) in Orlando, Fl. The AAFS
announced the award winners in the Foundation News in January. Congratulations,
Alex!
DR. JACKSON QUOTED IN NEWS STORY ON ALLEGATIONS OF EXPLOSIVES DURING "FREEDOM
CONVOY" IN OTTAWA IN FEB 2022 (JAN 2023)
Dr. Jackson was interviewed by Amanda Lamb, a reporter for WRAL, for her
new podcast series titled "What Remains." The series covers cold cases and the science of human remains.
Dr. Jackson described his
group's research that uses stable isotope ratio measurements of amino acids
in human hair to reveal lifestyle habits and biometric traits about the human
donors. Episode 16 of the podcast aired on October 26, 2022 and is available
at all major Podcast distributers.
WRAL's coverage of the episode is here.
DR. JACKSON QUOTED IN NEWS STORY ON ALLEGATIONS OF EXPLOSIVES DURING "FREEDOM
CONVOY" IN OTTAWA IN FEB 2022 (JAN 2023)
Dr. Jackson provided some context for a news story in
PressProgress
about the possibility that some grainy photographs of containers in the lobby
of a hotel in Ottawa contained images of hazardous chemicals.
PDF
DR. JACKSON APPEARS IN PODCAST SERIES "WHAT REMAINS" (OCT 2022)
DR. JACKSON'S WORK APPEARS IN DOCUMENTARY FOR SUNDANCE TV (SEPT 2022)
The series is titled "True crime story: It couldn't happen here." Although Dr. Jackson's recorded
interview was not featured in the final cut, the documentary (s1, e16 on
Iaeger, WV)) mentions the important contributions that Dr. Jackson made to
the exoneration of Jason Lively in 2020. Jason was convicted of murder and
arson in 2006 and served 14 years in prison. The story is described in other
venues, including the
Washington Post, the
WVU Innocence Project,
the
National Registry of Exonerations, and
Forensic Files II. The story was also described in
WVU Magazine in Oct 2022.
GROUP WELCOMES NEW MEMBERS (AUG 2022)
We welcome the introduction of several new group members this year. Alex Adeoye has transitioned from the MS program in FIS to the PhD program in forensic science. Courtney LaPointe has joined the group as a PhD student in Chemistry. Hannah McMillan has transitioned from the BS to the MS program in FIS. Finally, Chaney Ganninger, Sara Mosinski, and McKenna Oaks have joined the group as undergraduate researchers in FIS. Welcome All, and best wishes!
DR. JACKSON GIVES LIGHTNING TALK FOR ASCLD (JUNE 2022)
Along with Dr. Bob Wright of PNNL and Dr. David Morello of the DEA, Dr. Jackson
gave a virtual "lightning talk" on forensic applications of isotope ratio mass spectrometry
to the attendees of the American Society of Crime Laboratory Directors
(ASCLD). The series is organized by Dr. Ed Sisco of NIST, who leads the
Forensic Research Committee for ASCLD. Previous Lightning talks are
archived on Youtube. Dr. Jackson's talk can be
viewed on Youtube starting at 8:17.
DR. JACKSON INSTALLS CTD AT UNIVERSITY OF EVRY, FRANCE (JUNE 2022)
Dr. Jackson traveled to Université d'Évry Val-d'Essonne, part of the Paris-Saclay
University system on the south side of Paris, France, to install CTD-MS
capabilities on a Bruker amaZon Speed mass spectrometer in the laboratory
of Dr. Jean-Yves Salpin. Dr. Salpin is the director of research for the
CNRS Institute of Chemistry and a faculty member of the University of Évry.
The new installation will now serve several different research groups affiliated
with the CNRS platform and the University of
É
vry. Dr. Jackson previously completed a
CTD installation
in the the laboratory of Dr. David Ropartz and Dr. Hélène Rogniaux at INRAE
in Nantes in
2018
, so Dr. Salpin's laboratory is now the third group in the world to have
CTD-MS capabilities.